pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs

نویسندگان

h. rajaian

m. fazeli

j. jalaee

چکیده

six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. blood samples were collected before and at various time intervals after the administration of the drug. serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. noncompartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg.min and a volume of distribution of about 0.3 l/kg. the pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog.

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Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs

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عنوان ژورنال:
iranian journal of veterinary research

ناشر: shiraz university

ISSN 1728-1997

دوره 9

شماره 3 2008

کلمات کلیدی

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